HS is an isotonic crystalloid fluid, it remain isotonic after administration and are therefore effective volume expanders for a short period of time. However, both the water and the electrolytes in the solution can freely cross the semi-permeable membranes of the vessel walls (but not the cell membranes) into the interstitial space and will achieve equilibrium in two to three hours.
HS using for fluid replacement to support blood pressure from blood loss, it should be borne in mind that 3 ml of HS solution are needed to replace 1 ml of patient blood. This is because approximately two-thirds of the infused crystalloid solution will leave the vascular spaces by about one hour.
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